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TINs Roadmaps

We have developed roadmaps as tools to map out the development pathway for each therapeutic modality. Within the roadmaps, you are signposted towards the specific internal ÂÒÂ×Ðã and external resource that can provide support at each stage of the translational process.

Translational Training - ACCELERATE

Developed by the Academic Careers Office, ACCELERATE is a portfolio of activities aimed at upskilling the ÂÒÂ×Ðã research community in translational research through technical training, skills development, and encouraging innovative thinking. Here, also find other relevant training programmes across the university and educational resources beyond ÂÒÂ×Ðã. 

Informational Resources for Translational Research

Visit the Translational Research Office (TRO) website to view reports, papers, blog articles and other educational resources useful for those wishing to learn more about translational research and the extensive infrastructure in place at ÂÒÂ×Ðã to accelerate translation. 

TIN Webinar Recordings

We have made our online Therapeutic Innovation Networks events available to view as recorded webinars here. 

Developed by the National Institute for Health Research (NIHR), the Clinical Trials Toolkit provides practical advice to researchers in designing and conducting publicly funded clinical trials in the UK. Through the use of an interactive routemap, this site provides information on best practice and outlines the current legal and practical requirements for conducting clinical trials. [*Disclaimer]

An excellent digital tool from Oxford Global aimed at people working in the area of medical devices, helping researchers to navigate device and IVD regulations. [*Disclaimer]

Vigene designed this guide to help researchers decide which of the three most popular recombinant viruses, AAV, adenovirus, or lentivirus, will work best for their specific applications. [*Disclaimer]

In the Spring of 2020, Medicines Discovery Catapult (MDC) ran a series of 9 weekly webinars, MDC Connects, each comprising 2 or 3 different talks. This guide contains a write up summary of each presentation from the webinars, creating a great resource of modern drug discovery knowledge especially useful for the Small Molecules TIN. [*Disclaimer]

Another useful guide from the Medicines Discovery Catapult. This time on Complex Medicines (Biologics, ADCs etc.), and is based on the output from their 2021 focussed on complex medicines. [*Disclaimer]

In addition to the guide, the "Proposed Definition of ‘Complex Medicine" is a good resource especially for those in the Biologics TIN and can be found here:  

LifeArc and Pinsent Masons have developed a guide to 'Repurposing medicines:the opportunity and the challenges'. The guide includes lessons aimed at supporting charities and researchers that are researching new uses for existing medicines.  [*Disclaimer]

A careful lead optimization program is critical if a molecule is to progress successfully through preclinical studies and into clinical development. The initial leads that emerge from a hit-to-lead program, while they may show promising early signs of efficacy, may have features or properties that make them less likely to make a successful medicine.

Read more in the published by Fierce Biotech.  [*Disclaimer]

The national multi-agency Medicines Repurposing Programme identifies and progresses opportunities to use existing medicines in new ways, outside the current marketing authorisation or licence. This video explains which medicines are eligible, the support on offer, and our first successful licence variation for anastrozole. We are always searching for projects that use medicines in new ways to benefit patients. Source of the video: NHS England [*Disclaimer]

The Cell and Gene Therapy Catapult have created a resource to help therapy developers create a robust Target Product Profile (TPP). It acts as an ATMP developers guide to creating an evidence generation plan for successful therapy adoption. The guide outlines each of the attributes included in a TPP in detail, to help therapy developers navigate through the process, supporting the development of commercially viable products. [*Disclaimer]