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乱伦秀 Division of Medicine

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Intensive Care Medicine

The Bloomsbury Intensive Care Medicine Institute offers an internationally renowned critical care research programme and a very active experimental and clinical research portfolio. Our outputs range from new drugs and devices to novel insights into the pathophysiology underlying critical illness.

Prof. Mervyn Singer and colleagues explore the Wuhan response to managing critically ill patients in a novel disease pandemic, and lessons learnt for future pandemics.

Low-cost breathing aids developed by Mercedes High Performance Powertrains, University College London and University College London Hospital have been shipped to hospitals around the world in a life-saving partnership.

Our work

The centre is involved in the following research areas:

Pathology of critical illness

  • Mitochondrial dysfunction in critical illness.
  • Association between autonomic and immune dysfunction and relationship to postoperative complications.
  • Mechanisms of acute renal injury (P2X7 receptor activation).
  • Nitrite reductase activity in sepsis and hypoxaemia.

Novel monitoring and diagnostics

  • Tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
  • NADH redox state as a marker of the adequacy of tissue perfusion
  • Novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
  • Novel biomarkers for early detection of sepsis and infection
  • Development of a critical illness stress index.

Novel interventions

  • Long-acting sulphide donor therapy for ischaemia-reperfusion injury
  • Beta-blocker therapy in severe sepsis
  • Activators of mitochondrial biogenesis to enhance recovery from critical illness
  • CD73 therapy for acute lung injury
  • Patient-individualized targeted mobilization.

Our people

The Critical Care Trials team is the clinical research arm of the Bloomsbury Institute of Intensive Care Medicine. The team includes the聽clinical lead, Dr David Brealey, and 5.3 whole-time equivalent research nurses. We aim to attract and deliver a wide portfolio of studies that are pertinent not just to Critical Care but the whole Emergency Pathway. As such, we frequently work outside the physical walls of Critical Care, recruiting patients across the hospital from the Emergency Department to Day Case Chemotherapy.

Mervyn Singer portrait

Geoff Bellingan portrait

Basic silhouette in a circle, in light grey

Basic silhouette in a circle, in light grey

Basic silhouette in a circle, in light grey

Basic silhouette in a circle, in light grey

Basic silhouette in a circle, in light grey

Basic silhouette in a circle, in light grey

Dr Joseph Harris

Basic silhouette in a circle, in light grey

Dr Adarsh Kulkarni

Basic silhouette in a circle, in light grey

Dr Charles McFadyen

Basic silhouette in a circle, in light grey

Dr Francis Ryckaert

Basic silhouette in a circle, in light grey

厂迟耻诲别苍迟蝉听
  • Miranda Melis聽聽
  • Muska Miller (nee Khpal)
  • Naveed Saleem
  • Giacomo Stanzani
  • Robert Tidswell

Publications

  1. Rudiger A, Dyson A, Singer M, et al (2013)聽Clin Sci; 124:391-401.
  2. Ackland GL, Kazymov V, Singer M, et al (2013)聽Crit Care Med; 41:e85-92.聽
  3. Zolfaghari PS,聽Dyson A, Singer M, et al. (2013) Intensive Care Med Experimental.
  4. Morelli M, Donati A, Singer M, et al.聽(2013) Crit Care Med;41:2162-2168.
  5. Marty FM, Man CY,聽 Brealey D, et al. (2013) J Infect Dis.聽
  6. 聽Sachdev M, Brealey D, Singer M, et al.聽(2013) Crit Care; 17:R189.
  1. 聽Dyson A, Simon F,聽 Singer M, et al. (2012)聽 Intensive Care Med; 38:1868-76.
  2. Atlas G, Brealey D, Singer M, et al. (2012)聽. J Clin Monit Comput; 26:473-82.
  3. Adlakha A, Pavlou M, Singer M, et al. (2011) Int J STD AIDS; 22:498-504.
  4. Ackland GL, Dyson A, Singer M, et al. (2010). Crit Care Med; 38:629-36.
  5. Ackland GL,聽Dyson A, Singer M, et al. (2010) Crit Care Med; 38:388-94.

Funding and Partnerships

Wellcome Trust logo

British Heart Fundation logo

NIHR Logo

FP7 European Framework Programme Logo

European Commission Logo

The logo for the URKI Medical Research Council. A quadrilateral, with 'UKRI' over navy on the left, and two teal portions on the right.

Facilities

Mervyn Singer Lab is advanced in vivo monitoring of cardio-respiratory function, organ perfusion, tissue oxygenation, and metabolic monitoring Models of sepsis, haemorrhage (-reperfusion), haemodilution and both whole-body or organ-specific hypoxaemia(-reoxygenation).

  • Vascular cannulation
  • Mechanical ventilation
  • Echocardiography
  • Metabolic cart
  • Laser Doppler and Doppler flow monitoring
  • Tissue PO2 monitoring
  • Blood gas analyses
  • Ex vivo/in vitro respirometry
  • HPLC
  • Standard lab techniques (Westerns, PCR.)

Related Programmes聽

Our members contribute to the MBBS, iBSc, BSc and master鈥檚 degrees within the Division of Medicine. We provide BSc and MSc/MRes research project supervision. We also have an established track record in providing high-quality training to PhD students interested in basic, translational, and clinical research in the areas of lung cancer and airway stem cells.

Prizes

  • 2013 聽 聽UK Intensive Care Society Young Investigator Award (W Khaliq)
  • 2013 聽 聽UK Intensive Care Society Young Investigator Award (N Arulkumaran)
  • 2012 聽 聽MRC Centenary Award (Dr N Ekbal)
  • 2010 聽 聽UK Intensive Care Society Young Investigator Research Award (N Ekbal)
  • 2010 聽 聽European Society of Intensive Care Basic Science Award (J Morel)
  • 2009 聽 聽UK Intensive Care Society Young Investigator Research Award (S Barnes)
  • 2007 聽 聽European Society of Intensive Care Basic Science Award (J Carre)
  • 2007 聽 聽European Society of Intensive Care Intelligent Monitoring Award (A Dyson)
  • 2007 聽 聽UK Intensive Care Society Research Award (A Dyson)

Contact Details

m.singer@ucl.ac.uk
+44 (0)20 7679 6714

Postal & Visiting Address聽

Centre for Intensive Care Medicine
Cruciform Building
Gower Street
London
WC1E 6BT