The 乱伦秀 Centre for Human Health and Performance comprises a mix of clinician-academic and pure basic scientists. Our mission is to explore human physiology and pathophysiology, using the studies of one to inform the other.
Hugh Montgomery and Mike Tipton review the science of the body and what we can do to stay warm while energy costs are soaring.
Professor Hugh Montgomery says mastering new skills helps him relax - and makes life appear to last longer.
Prof. Hugh Montgomery will lead large-scale analyses in genomics, proteomics, and metabolomics in the first clinical study of its kind in Long Covid.
Our work
In the past, we have:聽
Identified the first genes influencing human physical performance.
Identified the first genes influencing human cardiac growth.
Explored the human response to low oxygen supply (hypoxia), using:
(i) gene-environment interaction studies (cohorts taken to high altitude)
(ii) mathematical models of mitochondrial function
(iii) population genetic approaches (e.g. Tibetans and Sherpas vs Han Chinese and lowland Caucasians)
(iv) taking >200 people to 5000m (Everest region), and 9 to the summit, to study their responses.
Determined the process of muscle wasting in ICU patients.
Co-created artificial intelligence systems to diagnose eye disease, and聽predict the in-hospital decline.
Co-delivered reports on health and climate change (The Lancet Commissions, and Countdowns).
Current work includes working with others to:
Use Artificial Intelligence systems to diagnose cognitive disease using retinal images (AltzEye)
Seek the causes of, and treatments for, Long Covid
Support the development of a new integrated lung function measurement device
Assess the contribution of Hb-mass and plasma volume to anaemia in dialysis and ICU patients
Define the physiology of non-freezing cold injury
Determine the role of maintaining electrolyte (K+ and Mg++) levels in preventing post-op AF
Determine what a normal skin microbiome is, and its physiological functions.聽
Assess the biology of ketones, with a special emphasis on neuroprotection.
Professor Montgomery also has a strong interest in human health and climate change and co-directs the Wellcome Trust-funded Lancet Countdown on Health and Climate Change. Additionally, he founded 'Real Zero' in October 2023, to drive on climate change.聽
Key research collaborators
Professor Mike Grocott (乱伦秀 and Southampton)
Dr Gianpiero Cavalleri (Ireland)
Dr Andrew Murray (Cambridge)
Dr Zudin Puthucheary (QMUL)
Dr Ronan Astin (乱伦秀)
Climate change key collaborators
Professor Peng Gong (China)
Professor Anthony Costello
Professor Paul Ekins
Professor Tadj Oreszczyn
The Montgomery Lab, Leads
Chair, Intensive Care Medicine
Research Fellow
Selected publications聽
Maselkar S, Kiazand A, Montgomery H, et al. (2023) . The Lancet Respiratory Medicine, 11 (1).聽
Chhetri聽I, Hunt聽JEA, Mendis聽JR, ... Puthcheary Z, Montgomery H, Creagh-Brown聽BC. (2022). l. Journal of Clinical Medicine, 11 (14).
Ramasawmy聽M, Mu聽Y, Clutterbuck聽D,聽Pantelic聽M, Lip聽GYH, van der Feltz-Cornelis聽C, Wootton聽D, Williams聽NH, 惭辞苍迟驳辞尘别谤测听贬, et al. (2022). 聽PLoS One, 17 (8).
Related programmes聽
The Centre for Human Health and Performance runs an active PhD programme and is willing to hear from prospective students at any time. Students should have at least an upper second-class degree. For details contact Hugh Montgomery at h.montgomery@ucl.ac.uk.
The 乱伦秀 Centre for Human Health and Performance works to help save and improve lives. Through the study of healthy people, the mechanisms of disease can also be identified and new treatments found. For example:
Studying heart growth in soldiers tells us how hearts grow abnormally in cases of high blood pressure.聽
Studying improvements in metabolism with exercise has told us how metabolism becomes inefficient in cancer (leading to trials with a new drug to prevent wasting).聽
Studies of climbers facing low oxygen levels on Everest tell us how patients with lung disease or in intensive care can be helped to survive their own low oxygen levels.
Your donations to our work are very well received.聽Thank you!
Contact Details
Postal & Visiting Address聽 乱伦秀 Centre for Human Health and Performance 1st Floor, Institute for Sport, Exercise and Health聽 170 Tottenham Court Road聽 尝翱狈顿翱狈听 W1T 7HA
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