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Cirrhosis
Consultant Hepatologist and liver expert Alastair O'Brien speaks to Cosmopolitan about how the sort of binge drinking associated with the Christmas period affects the body.
Tiny beads of carbon could save lives
乱伦秀 researchers have developed tiny carbon beads known as CARABLIVE to remove harmful bacteria from the gut and reduce inflammation inside the body.
Trial of smartphone app to manage cirrhosis is recruiting patients
A smartphone-enabled system to enhance the care of patients with severe liver disease who are being discharged from hospital听will be assessed in a trial led by 乱伦秀 and the Royal Free Hospital.
Alastair O'Brien responds to data that antibiotic prophylaxis failed to reduce the incidence of hospital-acquired infections or mortality among patients with decompensated cirrhosis.
Our work
Cirrhosis is the impaired liver function caused when scar tissue formed after liver disease gradually replaces normal functioning tissue. It can take years to develop.
Cirrhosis is often caused by alcoholic liver disease, heroin use, and chronic hepatitis B / C. Non-alcoholic steatohepatitis (NASH) can be caused by obesity, high blood pressure or cholesterol, type 2 diabetes, and metabolic syndrome.
It causes an array of symptoms, from fatigue, nausea and stomach pain, to swelling, jaundice and infections from fluid that collects in the abdomen. In serious cases, it can cause bleeding from swollen veins, or even liver cancer.
We completed the national ATTIRE trial (Albumin to prevent infection in chronic liver failure), and our ASEPTIC trial (Primary Antibiotic Prophylaxis using Cotrimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis) is now in the follow-up phase.
Professor O鈥橞rien is also the Clinical Director of the 乱伦秀 Comprehensive Clinical Trials Unit.
Our experts
Prof. Alastair O'Brien
Principal Investigator
Iulia Munteanu
Research nurse (Royal Free/乱伦秀H)
Marisa Chau
乱伦秀 CCTU: Clinical Project Manager
Nishtha Kotriwala
乱伦秀 CCTU: Data Manager
Leanne Crisp
乱伦秀 CCTU: Trial Manager
Tasheeka Jeyapalan
乱伦秀 CCTU: Trial Manager
Norin Ahmed
乱伦秀 CCTU: Statistics
乱伦秀 CCTU: Health Economics
乱伦秀 CCTU: PhD student
NHS collaborator (Royal Free)
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Selected publications
- China听L, Tittanegro听T, Crocombe听D, Forrest听E, Kallis听Y ...听O'Brien, A听(2023). . eClinicalMedicine, 58, 101924.
- Tittanegro听T, China听L, Forrest听E,听Kallis听Y, Ryder听SD ...听O'Brien听A听(2023). eClinicalMedicine, 55, 101716.
- Kutmutia听R, Tittanegro听T, China听L, Forrest听E, Kallis听Y, Ryder听SD ...听O'Brien, A听(2022). . American Journal of Gastroenterology.
- China L, Freemantle N, Forrest E, Kallis Y, Ryder SD, Wright G, O'Brien A (2021).听. Am J Gastroenterol. 2021 Nov 1;116(11):2292-2295.
- Maini AA, Becares N, China L, Tittanegro TH, Patel A, De Maeyer RPH, Zakeri N, Long TV, Ly L, Gilroy DW, O'Brien A听(2021). . JHEP Rep. 2021 Aug 4;3(6):100332. eCollection 2021 Dec.
- China听L, Freemantle听N, Forrest E, Kallis听Y, Ryder听SD, Wright G听... O'Brien A,听ATTIRE Trial Investigators听(2021). . The New England Journal of Medicine, 384 (9), 808-817.
- Aithal GP, Palaniyappan N, China L, H盲rm盲l盲 S, Macken L, Ryan JM, Wilkes EA, Moore K, Leithead JA, Hayes PC, O'Brien AJ, Verma S (2020). . Gut 2020.
- Becares N, H盲rm盲l盲 S, China L, Colas RA, Maini AA, Bennet K, Skene SS, Shabir Z, Dalli J, O'Brien A (2019). . Clin Gastroenterol Hepatol. 2019 Aug 22. pii: S1542-3565(19)30911-5.
- China L, Maini A, Skene S, Shabir Z, Sylvestre, Colas R, Ly L, Becares Salles N, Belloti V, Dalli J, Gilroy DW & O'Brien AJ听(2017). . Clin Gastroenterol Hepatol. 2017 Aug 28. pii: S1542-3565(17)30993-X.
- O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Newson J, Karra E, Winstanley A, Alazawi W, Garcia-Martinez R, Cordoba J, Nicolaou A, Gilroy DW (2014). . Nature Medicine. 2014;20(5):518-23.
Funding and partnerships
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