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Early Phase Cancer Trials Programme at ÂÒÂ×Ðã and ÂÒÂ×ÐãH

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Brain Trials

A LIST OF OUR EARLY PHASE brain cancerÌýTRIALS WHICH ARE OPEN TO RECRUITMENT AT UNIVERSITY COLLEGE LONDON HOSPITALs

To find more information on ÂÒÂ×ÐãH Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the ÂÒÂ×ÐãH Find a Study database.

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CITADEL-123

A Phase I clinical trial to assess the activity of I-123 Poly Adenosine Diphosphate Ribose Polymerase I inhibitor (123I-ATT001) directly administered in subjects with relapsed glioblastoma

Local Project Reference:
Principal Investigator:Dr Paul Mulholland
Drug Class/ Treatment:

123I-ATT001Ìý(I-123 Poly Adenosine Diphosphate Ribose Polymerase I inhibitor)

Intracavitary instillation

Patient Population:Relapsed Glioblastoma
Trial Hosted By - ÂÒÂ×ÐãH Clinical Research Facility (CRF)

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LOXO-RET-18036

A Phase 1/2 Study of the Oral RET Inhibitor LOXO-292 in Pediatric Patients with Advanced RET-Altered Solid or Primary Central Nervous System TumoursÌý

Local Project Reference:
Principal Investigator

Dr Sara Stoneham

Drug Class/ Treatment:

Selpercatinib (LOXO-292)Ìý(RET Inhibitor)

Patient Population:

Paediatric patients ≥ 6 months of age and ≤ 21 years of age at Cycle 1 Day 1 (C1D1)

  • RET fusion-positive solid tumor with measurable disease
  • RET-mutant MTC with measurable disease
  • RET fusion-positive primary CNS tumor with measurable disease.

Trial Hosted By - ÂÒÂ×ÐãH Cancer Clinical Trials Unit (CCTU)

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