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Thursday, 27 June 2024:ÌýÂÒÂ×Ðã Senior Promotions 2023-24 in GGM

Dr Haiyan Zhou (Molecular Basis of Rare Diseases) to Professor of Genetic Medicine

Dr Naresh Hanchate (Molecular Basis of Rare Diseases) toÌýPrincipal Research Fellow

Tuesday, 18 June 2024:ÌýÌýBlood test could predict Parkinson’s seven years before symptoms

A team of researchers, led by scientists at ÂÒÂ×Ðã including senior authorÌýProfessor Kevin Mills, co-authorÌýDr Jenny Hällqvist and GGM colleagues,Ìýand University Medical Center Goettingen, Germany, have developed a simple blood test that uses artificial intelligence (AI) to predict Parkinson’s up to seven years before the onset of symptoms.

Monday, 10 June 2024:ÌýÌýNew blood test could prevent sudden child deaths caused by heart condition

A new blood test that could identify children with a potentially fatal heart condition has been developed by researchers at ÂÒÂ×Ðã and Great Ormond Street Hospital (GOSH), including co-author Professor Kevin Mills (GGM).

Monday, 20 MayÌý2024:ÌýMaria Bitner-Glindzicz Travel and Conference Fund is now openÌýfor applications.

Deadline is 5pm Wednesday 18 SeptemberÌý2024.Ìý

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Research Fellow - closing date 18/09/2024

This is an excellent opportunity to work on a newly funded UKRI Medical Research Council (MRC) project. The successful applicant will be working as part of a newly set up group led by Dr Naresh Hanchate, who is a ÂÒÂ×Ðã Excellence Fellow and the holder of the MRC Neuroscience and Mental Health New Investigator Award. The aim of the Hanchate group is to investigate the impact of early life adversities on the brain circuitry, in particular, those that control physiological stress responses. The group employs newly developed genomic technologies (Connect-seq, Nuc-connect-seq) to profile single-cell transcriptomes of individual neural circuit components to understand the impacts of early life adversities. The postholder will perform murine studies, including maintenance of transgenic lines, behavioral and physiological studies, surgical manipulations for stereotaxic delivery of viruses intracranially, preparation of single-cell cDNA libraries, sequencing, and analyses or arrange work with ÂÒÂ×Ðã Genomics, supervision of undergraduate and graduate students. The post is funded until 31 Jan 2026 in the first instance and the salary range for this post is £42,099 - £46,732 per annum.

Research Assistant - closing date 22/09/2024

The successful applicant will have the exciting opportunity to investigate a novel way to target the blood brain barrier (BBB) for increased access for systemically administered larger therapeutic access to the central nervous system (CNS), with proof-of-concept work in vitro and in vivo, alongside targeting a rare neurodegenerative disease for downstream translational application, using cutting-edge models and tools. This project will provide a novel proof-of-concept data. The project will use mRNA-LNP technology to transiently alter BBB permeability in vitro in different models. The successful applicant will use implement various standard laboratory techniques such as RT-qPCR, in-cell western, western blot, immunocytochemistry alongside cell viability and cellular toxicity assays to assess efficacy and toxicity of the mRNA-LNPs. The project will further generate proof-of-concept in vivo. Please see the job description for more details.