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Prof Sandra Strauss - Chair

Prof Sandra Strauss, MBBS FRCP PhD

Sandra Strauss
is a Professor of Medical and TYA Oncology at University College London听and Honorary Consultant Medical Oncologist. Her clinical post is based at University College London Hospital, part of the London Sarcoma Service, one of the largest sarcoma services in Europe. She specialises in the systemic treatment of bone and soft tissue sarcomas in both adults and teenagers.

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Sandra began training as a medical oncologist working on the adolescent unit at the Middlesex Hospital where she developed an interest in sarcoma and teenage and young adult (TYA) cancer. She completed a Cancer Research UK Clinical Fellowship to obtain a PhD (University of London) at St Bartholomew's Hospital investigating pre-clinical and clinical effects of novel treatments for cancer, and investigating translational markers to improve their effects. In 2009, she was awarded a Career Development Award from the Sarcoma Alliance for Research through Collaboration (SARC), which allowed her to further her research aiming to identify new targets for the treatment of sarcoma; work that is ongoing in the 乱伦秀 Cancer Institute. She has a strong interest in translating these findings into benefit for patients and early phase clinical trials, particularly in sarcomas affecting teenagers and young adults.

She is the chief investigator and principal investigator for a number of international and national phase I, II and III studies in sarcoma and is leading a national cohort study in osteosarcoma, ICONIC. She chairs the NCRI Sarcoma Clinical Studies Group Bone Subgroup and was recently appointed Chair of the Executive Committee of the European Euro Ewing Consortium (EEC), a pan-European collaboration to improve outcome for patients with Ewing sarcoma. She is a member of the EORTC Soft Tissue and Bone Sarcoma Group and Innovative Therapies for Children with Cancer (ITCC) consortium and is the Clinical lead for Sarcoma and rare cancers for the Public Health England (PHE) National Cancer Registration and Analysis Service (NCRAS). Here, she is particularly interested in understanding variations in patient pathways and access to specialist services to reduce inequalities and improve outcome for patients with rare cancers.

Selected Publications

  1. Younger E, Smrke A, Lidington E, Farag S, Ingley K, Chopra N, Maleddu A, Augustin Y, Merry E, Wilson R, Benson C, Miah A, Zaidi S, McTiernan A, Strauss SJ, Dileo P, Gennatas S, Husson O, Jones RL. . Cancers 2020 Aug 14;12(8):E2288. doi: 10.3390/cancers12082288
  2. Gennatas S, Chamberlain F, Carter T, Slater S, Cojocaru E, Lambourn B, Stansfeld A, Todd R, Verrill M, Ali N, Jones RL, Simmonds P, Keay N, McCarty H, Strauss S,et al. . Clin Sarcoma Res. 2020 May 6;10:9. doi: 10.1186/s13569-020-00131-x.
  3. Anderton J, Moroz V, Marec-B茅rard P, Gaspar N, Laurence V, Mart铆n-Broto J, Sastre A, Gelderblom H, Owens C, Kaiser S, Fern谩ndez-Pinto M, Fenwick N, Evans A, Strauss S, Whelan J, Wheatley K, Brennan B. . Trials. 2020 Jan 17;21(1):96. doi: 10.1186/s13063-019-4026-8.
  4. Prendergast SC, Strobl AC, Cross W, Pillay N, Strauss SJ, Ye H, Lindsay D, Tirabosco R, Chalker J, Mahamdallie SS, Sosinsky A; RNOH Pathology Laboratory and Biobank Team; Genomics England Research Consortium, Flanagan AM, Amary F. . J Pathol Clin Res. 2020 Jun 23. doi: 10.1002/cjp2.174. Online ahead of print.
  5. Steele CD, Tarabichi M, Oukrif, D; Webster, AP; Ye H; Fittall, M; Lombard, P; Martincorena, I; Tarpey, PS; Collord, G; Strauss, SJ, et al, 2019 Cancer Cell 18;35(3):441-456.e8.
  6. Smeland S, Bielack SS, Whelan J, Strauss S, et al. . Eur J Cancer. 2019 109:36-50.
  7. Casali PG, Bielack S, Abecassis N, Aro HT, Bauer S, Biagini R, Bonvalot S, Boukovinas I, Bovee JVMG, Brennan B, Brodowicz T, Broto JM, Brugi猫res L, Buonadonna A, De 脕lava E, Dei Tos AP, Del Muro XG, Dileo P, Dhooge C, Eriksson M, Fagioli F, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gaspar N, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hecker-Nolting S, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kager L, Kasper B, Kopeckova K, Kr谩korov谩 DA, Ladenstein R, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Morland B, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Sch枚ffski P, Sleijfer S, Stacchiotti S, Strauss SJ, et al. ; Ann Oncol. 2018 Oct 1;29(Supplement_4):iv79-iv95. doi: 10.1093/annonc/mdy310.
  8. Strauss SJ, Whelan JS. . Curr Opin Oncol. 2018 Jul; 30(4):252-259.听DOI:听10.1097/CCO.0000000000000456
  9. Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ*, Lord CJ*. . Sci Rep. 2018 Jul 13;8(1):10614. doi: 10.1038/s41598-018-29043-z听*corresponding authors
  10. Strauss, SJ, Anninga, J; Baglio, R; Baumhoer, D; et al. , Clin Sarcoma Res,听 2018; 8:17;听听 https:// doi.org / (epub)
  11. Sch枚ffski,P; Kasper,B; Aamdal,S; Leahy,M; Rutkowski,P; Bauer,S; Gelderblom,H; Italiano,A; Lindner,LH; Hennig,I; Strauss,S;听 et al. . Lancet Respiratory Medicine 2018 Jun;6 (6):431-441听DOI:听10.1016/S2213-2600(18)30116-4
  12. Sch枚ffski,P; Wozniak,A; Kasper,B; Aamdal,S; Leahy,M; Rutkowski,P; Bauer,S; Gelderblom,H; Italiano,A; Lindner,LH; Hennig,I; Strauss,S;听 et al. . European Organization for Research and Treatment of Cancer (EORTC) phase 2 trial 90101 "CREATE". 2017 Ann Oncol. 2017 29(3):758-765听DOI:听10.1093/annonc/mdx774
  13. Sch枚ffski P, Wozniak A, Casali PG, Rutkowski P, Blay JY, Lindner LH, Strauss SJ, et al. . 2017 Ann Oncol. 2017 Dec 1;28(12):3000-3008听DOI:听10.1093/annonc/mdx527
  14. Seddon B, Strauss SJ, Whelan J, et al.听 .听 Lancet Oncol. 2017 18(10):1397-1410听DOI:听10.1016/S1470-2045(17)30622-8
  15. Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KL, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PC, Isakoff MS, Janeway KA, J眉rgens H, Kager L, K眉hne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MC, Strauss SJ,et al. . Lancet Oncology 2016 17(10):1396-1408.听DOI:听10.1016/S1470-2045(16)30214-5
  16. Rothermundt C, Seddon BM, Dileo P, Strauss SJ, et al. . BMC Cancer. 2016 16(1):301.听DOI:听10.1186/s12885-016-2333-y
  17. Scheipl S, Barnard M, Cottone L, Jorgensen M, Drewry DH, Zuercher WJ, Turlais F, Ye H, Leite AP, Smith JA, Leithner A, M枚ller P, Br眉derlein S, Guppy N, Amary F, Tirabosco R, Strauss SJ, Pillay N, Flanagan AM. . J Pathol. 2016 Apr 22. doi: 10.1002/path.4729.听DOI:听10.1002/path.4729
  18. Campbell J, Ryan CJ, Brough R, Bajrami I, Pemberton HN, Chong IY, Costa-Cabral S, Frankum J, Gulati A, Holme H, Miller R, Postel-Vinay S, Rafiq R, Wei W, Williamson CT, Quigley DA, Tym J, Al-Lazikani B, Fenton T, Natrajan R, Strauss SJ, Ashworth A, Lord CJ. . Cell Rep. 2016 (16)30126-7.听DOI:听10.1016/j.celrep.2016.02.023
  19. Kager L, Whelan J, Dirksen U, Hassan B, Anninga J, Bennister L, Bov茅e JV, Brennan B, Broto JM, Brugi猫res L, Cleton-Jansen AM, Copland C, Dutour A, Fagioli F, Ferrari S, Fiocco M, Fleuren E, Gaspar N, Gelderblom H, Gerrand C, Ger脽 J, Gonzato O, van der Graaf W, Hecker-Nolting S, Herrero-Mart铆n D, Klco-Brosius S, Kovar H, Ladenstein R, Lancia C, LeDeley MC, McCabe MG, Metzler M, Myklebost O, Nathrath M, Picci P, Potratz J, Redini F, Richter GH, Reinke D, Rutkowski P, Scotlandi K, Strauss S, et al. Clin Sarcoma Res. 2016 Mar 16;6:3听DOI:听10.1186/s13569-016-0043-5
  20. Ban J, Fourtouna A, Aryee D, van der Ent W, Kauer M, Niedan S, Machado I, Rodriguez-Galindo C, Tirado OM, Alberghini M, Flanagan AM, Berg V, Strauss SJ, Scotlandi K, Lawlor ER, Snaar-Jagalska E, Llombart-Bosch A, Kovar H.听听听 . Cancer Research, 2014 74 (22):6578-88.
  21. Koelblinger C1, Strauss S, Gillams A.. Cardiovasc Intervent Radiol. 2014 Feb;37(1):147-53.
  1. Rothermundt C, Whelan JS, Dileo P, Strauss SJ, et al. . Br J Canc, 2014.
  1. Fernanda AM, Ye H, Berisha F, Khatri B, Forbes G, Lehovsky K, Frezza AM, Behjati S, Tarpey P, Pillay N, Campbell PJ, Tirabosco R, Presneau N, Strauss SJ, Flanagan AM. . 听2014.
  1. Frezza AM, Beale T, Bomanji J, Jay A, Kalavrezos N, Dileo P, Whelan J, Strauss SJ.听 BMC Cancer. 2014 Jan 15;14(1):23. doi: 10.1186/1471-2407-14-23.
  1. Mendoza-Naranjo, A, El-Naggar A, Wai DH, Zhu Q, Mistry P, Lazic N, Ayala F, da Cunha I, Rodriguez-Viciana P, Farrar JE, Soares FA, Flanagan A, Reynolds P, Triche T, Arceci RJ, Strauss SJ, Sorensen PHB. . EMBO Molecular Medicine, 2013 May 16. doi: 10.1002/emmm.201202343.
  1. Whelan J, Khan A, Sharma A, Dileo P, Michelagnoli M, Seddon B, Strauss S. . Clin Sarcoma Res. 2012
  1. Lombardo CM, Welsh SJ, Strauss SJ, et al. . Bioorg Med Chem Lett. 2012 Sep 15;22(18):5984-8. doi: 10.1016/j.bmcl.2012.07.009. Epub 2012 Jul 14.
  1. Whelan JS; Mctiernan, A; Cooper, N; Francis, M; Strauss SJ. , Int Journal of Cancer, 15;131(4):E508-17, 2012.
  1. Windsor R; Strauss SJ et al. . Cancer 118(7), 2012.
  1. Strauss SJ, Ng T, Mendoza-Naranjo A. . The Oncologist 15(6):627-35, 2010.
  1. Turner NC, Strauss SJ, Sarker D, Gillmore R, Kirkwood A, Hackshaw A, Papadopoulou A, Bell J, Kayani I, Toumpanakis C, Grillo F, Mayer A, Hochhauser D, Begent RH, Caplin ME, Meyer T. .听 Br J Cancer. 2010 Mar 30;102(7):1106-12. doi: 10.1038/sj.bjc.6605618. Epub 2010 Mar 16.
  1. Strauss SJ, Higginbottom K, J眉liger S, Maharaj L, Allen P, Schenkein D, Lister TA, Joel SP. . Cancer Res. 2007 Mar 15;67(6):2783-90.
  1. Strauss, SJ F Morschauser, M Gramatzki,et al.听 . J Clin Oncol 24(24); 3880-6, 2006.
  1. Strauss SJ, L Maharaj, S. Hoare, et al.听 . J Clin Oncol 24(13):2105-12, 2006
  1. Strauss SJ, McTiernan A, Whelan JS.听 .听 Pediatr Blood Cancer 43 (6): 692 鈥� 697, 2004.
  1. Strauss SJ, McTiernan A, Driver D, et al.听 .听 J Clin Oncol 21(15), 2003