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Led by Elise Parey and co-authored by Paola Oliveri and Ferdinand Marlétaz, theÌýstudy unveiled the first-ever genome sequence of these mysterious marine creatures. Brittle stars, a class of echinoderms, have long intrigued scientists due to their ecological significance. Despite their importance,Ìýthey remained the last echinoderm group without a fully sequenced genome. The team aimed to address this gap while also exploring the evolutionary conservation of regeneration - a topic that continues to captivate the scientific community.

The study focused on the genes responsible for brittle star appendage regeneration. By comparing these genes with those of other animals, the researchers made a remarkable discovery: a set of conserved genes controlling regenerative processes across diverse animal groups, from crustaceans to vertebrates. This finding suggests an ancient origin of regeneration in the animal kingdom.

Moreover, the study revealed that brittle stars possess highly dynamic genomes - more so than other echinoderms. The researchers identified an expansion of genes associated with regenerative potential, emphasising the need to study diverse models to unravel the intricate mechanisms governing universal biological processes like regeneration.

Dr Ferdinand Marlétaz, Royal Society University Research Fellow in the Department of Genetics, Evolution & Environment (ÂÒÂ×Ðã Biosciences), said: “Brittle stars are present in all the marine environments, and still little is known about the molecular base of their adaptations, such as their incredible regeneration capabilities.Ìý To me, this study shows the importance of increased taxonomic sampling (considering multiple lineages) for comparative studies."

This groundbreaking research underscores the importance of interdisciplinary collaboration and highlights the significance of studying lesser-known organisms. As we delve deeper into the genetic blueprints of life, we gain a clearer understanding of our shared biological heritage.

Further information:

• Research Department of Genetics, Evolution and Environment
• Division of Biosciences
• Faculty of Life Sciences

Image Credit:

Ferdinand Marlétaz

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